The lab works on spiders and has even managed to create new species of 'super-spiders' through genetic DNA manipulation and combination. Peter's science class takes a field trip excursion to a genetics science laboratory at Columbia University. Norman, the founder, owner and head of weapons contractor of Oscorp Science Industries, appreciates Peter's scientific aptitude and can barely conceal his desire that Peter was his own son. Harry, however, is somewhat jealous of the affection his billionaire scientist father, Professer Norman Virgil Osborn (Willem Dafoe) shows Peter.

Peter's only friend is Harold Theopolis 'Harry' Osborn (James Franco), who, though rich and good-looking, is similarly an outcast. Her boyfriend, a sports player and the school bully, Eugene 'Flash' Thompson (Joe Manganiello) and his buddies bully and pick on him. He has a crush on his next door neighbor, Mariam 'Mary' Jane Watson (Kirsten Dunst), who is also one of the few classmates who is nice to him. His parents are dead and he lives with his Uncle Benjamin Franklin 'Ben' Parker (Cliff Robertson) and Aunt Mayabella 'May' Parker (Rosemary Harris). Yeo, Octavia Spencer, Pete Macnamara, Peter Appel, Peter Aylward, Philip Ng, Rachael Bruce, Randy Savage, Rick Avery, Robert Kerman, Ron Perkins, Rosemary Harris, Sally Levi, Sara Ramirez, Scott L.Peter Benjamin Parker (Tobey Maguire) is a nerdy and shy but intelligent high school senior student at Midtown Secondary College Of Science & Technology in Queens, New York City. Dodds, Kirsten Dunst, Kristen Davidson, Kristen Marie Holly, Larry Joshua, Laura Gray, Leroy Patterson, Lindsay Thompson, Lisa Danielle, Loren Janes, Lucy Lawless, Mackenzie Bryce, Macy Gray, Maribel González, Mark De Alessandro, Martin Pfefferkorn, Matt Smith, Michael Edward Thomas, Michael Papajohn, Myk Watford, Natalie T. Brown, Joseph D’Onofrio, Joy Michelle Moore, Julia Barrie, K. Simmons, Jack Betts, James Franco, Jason Padgett, Jayce Bartok, Jeanie Fox, Jesse Heiman, Jill Sayre, Jillian Clare, Jim Norton, Jim Ward, Joe Manganiello, Joe Virzi, John Paxton, Johnny Trí Nguyễn, Jophery C.

Williams, Bruce Campbell, Chris Coppola, Cliff Robertson, Corey Mendell Parker, David Holcomb, Deborah Wakeham, Elizabeth Banks, Erica D.

Cast: Ajay Mehta, Alex Black, Amy Bouril, Andray Johnson, Ashley Edner, Benny Urquidez, Bill Calvert, Bill Nunn, Brad Grunberg, Brian J.

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